The queen "died peacefully" on Thursday afternoon at Balmoral Castle, her estate in the Scottish Highlands, royal family officials announced.
Her son Charles, 73, is now king. Officials said he remains at Balmoral and will return to London on Friday.
"The death of my beloved Mother, Her Majesty The Queen, is a moment of the greatest sadness for me and all members of my family," Charles said in a statement. "We mourn profoundly the passing of a cherished Sovereign and a much-loved Mother. I know her loss will be deeply felt throughout the country, the Realms and the Commonwealth, and by countless people around the world."
Elizabeth acceded to the throne on Feb. 6, 1952. Over her 70-year-long reign, she oversaw an extraordinary period of British history, including decolonization and the independence of more than 20 countries that were once a part of the British Empire. Fifteen British Prime Ministers came and went during her reign, along with 14 U.S. Presidents.